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WARNINGS Respiratory Depression At high doses or in sensitive patients, hydrocodone may produce dose -related respiratory depression by acting directly on the brain stem respiratory center.
Hydrocodone also affects the center that controls respiratory rhythm, and may produce irregular and periodic breathing. Head Injury And Increased Intracranial Pressure The respiratory depressant effects of narcotics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure. Furthermore, narcotics produce adverse reactions which may obscure the clinical course of patients with head injuries.
Acute Abdominal Conditions The administration of narcotics may obscure the diagnosis or clinical course of patients with acute abdominal conditions.
The usual precautions should be observed and the possibility of respiratory depression should be kept in mind. Carcinogenesis, Mutagenesis, Impairment of Fertility No adequate studies have been conducted in animals to determine whether hydrocodone or acetaminophen have a potential for carcinogenesis, hydrocodone 5 500 street price, mutagenesisor impairment of fertility.
Pregnancy Teratogenic Effects Pregnancy Category C There are no adequate and well-controlled studies in pregnant women. Nonteratogenic Effects Babies born to mothers who have been taking opioids regularly prior to delivery will be physically dependent.
500 The withdrawal signs include irritability and excessive crying, tremors, hyperactive reflexes, increased respiratory rateincreased stools, sneezing, yawningvomiting and fever, hydrocodone 5 500 street price. The intensity of the syndrome hydrocodone not always correlate price the duration of maternal opioid use or dose.
There is no consensus on the best method of managing street.
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Labor And Delivery As with all narcotics, administration of this product to the mother shortly before delivery may result in some degree of respiratory depression in the newborn, especially if higher prices are used.
500 Mothers Acetaminophen is excreted hydrocodone breast milk in small streets, but the significance of its effects on nursing infants is not known, hydrocodone 5 500 street price.
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It is not known whether hydrocodone is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from hydrocodone and acetaminophen, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
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hydrocodone Pediatric Use Safety and effectiveness in pediatric patients have not been established. Geriatric Use Clinical studies of hydrocodone bitartrate 5 mg and acetaminophen mg did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger streets. In general, dose selection for an elderly 500 should be cautious, usually starting at the low end of the dosing range, reflecting the greater price of decreased hepatic, renal, hydrocodone 5 500 street price, or cardiac function, and of concomitant disease or other drug therapy.
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Hydrocodone and the major metabolites of acetaminophen are known to be substantially excreted by the kidney. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, 500 it may be useful to price hydrocodone function. Hydrocodone may cause confusion and over-sedation in the elderly; elderly streets generally should be started on low doses of hydrocodone bitartrate and acetaminophen tablets and observed closely.